The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice. K. J. ROGERS. Departments of Pharmacology and Anaesthetics, University of Sheffield A critical level of this monoamine, in the brain, may be necessary before the drug interaction will take place. Citing Literature. Vol Issue :// There has been a recent renewal of interest in the use of monoamine oxidase inhibitors, but the concurrent administration of narcotic analgesics is often a cause for concern. This review clarifies the different types of MAOI/narcotic interactions and offers guidelines for the use of narcotic analgesics in the presence of :// The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice ROGERS, K. J.; THORNTON, J. A. Departments of Pharmacology and Anaesthetics, University of Sheffield 1. The administration of either iproniazid or tranylcypromine to mice potentiates the acute toxicity of The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice. (PMID PMCID:PMC) Full Text Citations LEESON GA, PHILLIPS GE. An effect of monoamine oxidase inhibitors on brain serotonin of mice in addition to that resulting from inhibition of monoamine oxidase. J
Ever since the discovery of the MAOI anti-tuberculous drug iproniazid, in the mids, there have been concerns about interactions between MAOI antidepressant drugs, including new reversible inhibitors of monoamine oxidase-A (RIMAs) typified by moclobemide, and analgesics used in anaesthesia. 9 14 57 58 71 74 This topic continues to be 4naesthesia, , Vol pages 'CISE REPORT Anaesthesia and the new generation monoamine oxidase inhibitors H. J. McFARLANE Summary The new generation nionoaniine oxidase inhibitors are short acting and specific for nionoaniine osidase A. Evidence to date aggests that there is little potential for significant interaction with niost drugs used in :// the use of monoamine oxidase inhibitors in psychiatry. The concurrent administration of anaesthetic agents. particularly narcotic analgesics, is often a cause for concern. Although many monoamine oxidase inhibitor-drug inter-actions have been reported, in practice it is only the interaction with pethidine which has led to :// Rapaport MH. Dietary restrictions and drug interactions with monoamine oxidase inhibitors: the state of the art. J Clin Psychiatry , 68(suppl 8) Berlin I, Lecrubier Y. Food and drug interactions with monoamine oxidase inhibitors – how safe are the newer agents? CNS Drugs , Nicholson, :// Web view.
The most storied interaction of relevance to dentists was the putative interaction between epinephrine and the monoamine oxidase inhibitors. It was believed that inhibition of MAO could potentiate the activity of epinephrine by delaying its :// Monoamnine Oxidases. Antidepressant activity of monoamine oxidase inhibitors (MAOIs) was initially noted in the s. Although older monoamine oxidase inhibitors (MAOIs) are effective in the treatment of depressive disorders, they are under-utilized in clinical practice due to main concerns about interaction with tyramine-containing food (matured cheese, red vine, ripped bananas, yogurt *Monoamine Oxidase Inhibitors Metoclopramide should be used cautiously, if at all in patients receiving monoamine oxidase inhibitors. *Anticholinergic Drugs and Opioid Analgesics Anticholinergic drugs and narcotic analgesics may antagonise the effects of metoclopramide on gastrointestinal motility. No significant interaction Canadian Medical Association Journal ; Rogers KJ. Role of brain monoamines in the interaction between pethidine and tranylcypromine. European Journal of Pharmacology ; Rogers KJ, Thornton JA. The interaction between monoamine oxidase inhibitors and narcotic analgesics in mice. British Journal of Pharmacology ; 36